Following the positive feedback received from a series of successful trials, Hanningfield is proud to officially launch the latest product in its range of dust containment solutions; the Uni-Cap.
The silicone rubber caps offer the ultimate in hygienic powder-transfer, helping to protect both operators and the process environment. Easy to clean and available in various sizes, the Uni-Cap is an ideal and cost-effective solution to powder transfer problems. For more details on this, or how Hanningfield can help to improve various aspects of your powder transfer system, please feel free to contact us.
Pharmaceutical Process Equipment
Sunday, 27 July 2008
Friday, 25 July 2008
Gene Variation May Raise Risk of HIV, Study Finds
A genetic variation that protected people in sub-Saharan Africa from a now-extinct form of malaria could also have left their ancestors more vulnerable to HIV, according to a new study by US and UK researchers. The variation in a single unit of DNA could account for 11 percent of the HIV infections in Africa, they suggest.Among those who carry this single nucleotide polymorphism (SNP), the surface of red blood cells lack the Duffy antigen receptor that receives a signal from the hormone CCL5, part of the immune system\'s regulatory system.
About 10,000 years ago, it conferred protection to humans against the malarial parasite Plasmodium vivax. More than 90 percent of Africans and about 60 percent of African-Americans lack the receptor.The study involved Air Force members whose HIV infections have been followed for 25 years. African Americans who carried the SNP were 50 percent more likely to acquire HIV than African Americans who did not. However, the disease among carriers progressed more slowly, researchers noted.The finding "would be pretty exciting if it holds up," said David B. Goldstein, a geneticist who studies HIV at Duke University. "If the results are confirmed, it would mean that selection for resistance to malaria has created vulnerability to infection with HIV-1."The exact mechanism promoting HIV infection is not certain, said Dr. Sunil K. Ahuja, director of the Veteran Administration HIV/AIDS Center-San Antonio.
However, CCL5 is known to obstruct HIV\'s proliferation, and the red blood cells act like a sponge for CCL5, which may help prevent HIV infection.The study, "Duffy Antigen Receptor for Chemokines Mediates Trans-Infection of HIV-1 from Red Blood Cells to Target Cells and Affects HIV-AIDS Susceptibility," was published in Cell Host & Microbe.
http://www.hanningfield.com/about/news/
About 10,000 years ago, it conferred protection to humans against the malarial parasite Plasmodium vivax. More than 90 percent of Africans and about 60 percent of African-Americans lack the receptor.The study involved Air Force members whose HIV infections have been followed for 25 years. African Americans who carried the SNP were 50 percent more likely to acquire HIV than African Americans who did not. However, the disease among carriers progressed more slowly, researchers noted.The finding "would be pretty exciting if it holds up," said David B. Goldstein, a geneticist who studies HIV at Duke University. "If the results are confirmed, it would mean that selection for resistance to malaria has created vulnerability to infection with HIV-1."The exact mechanism promoting HIV infection is not certain, said Dr. Sunil K. Ahuja, director of the Veteran Administration HIV/AIDS Center-San Antonio.
However, CCL5 is known to obstruct HIV\'s proliferation, and the red blood cells act like a sponge for CCL5, which may help prevent HIV infection.The study, "Duffy Antigen Receptor for Chemokines Mediates Trans-Infection of HIV-1 from Red Blood Cells to Target Cells and Affects HIV-AIDS Susceptibility," was published in Cell Host & Microbe.
http://www.hanningfield.com/about/news/
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